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471 To enhance the delivery of neutrally charged oligonucleotides, Gait and Wood 472 developed a series of arginine-rich CPPs named [PNA/PMO]-internalized peptides (Pip), including Pip2a, Pip2b, Pip5e, and Pip6a

Whole blood tubes and serum microfuge tubes were refrigerated and then picked up by a courier and outsourced for analysis (Quest Diagnostics, Waco, TX) within 2 h

There were no significant changes in the control group for any outcomes or measurements

Recent research has focused on the unique pharmacokinetics of linagliptin, specifically the high plasma protein binding and long half-life, which may be exploited for tailored dosing in various clinical conditions, including specific patient populations [22]