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In clinical studies, liraglutide and semaglutide both led to an average 0.3-point drop in A1c in prediabetic participants (after 56 weeks for liraglutide 5 and 68 weeks for semaglutide 6 )a small but meaningful shift for people whose blood sugar is creeping upward toward the diabetes threshold

For example, the LEADER trial showed that Liraglutide significantly reduced the risk of major adverse cardiovascular events (MACE) by 13% and cardiovascular death by 22% in comparison to placebo

Some people feel slightly more tired, while others feel no change at all

Therefore, the aforementioned novel applications of GLP-1RAs all have the potential to bolster treatment and management options for the field as a whole, and new research continues to illuminate the physiological mechanisms behind this observed neuroprotective effect

*Correspondence: Jixin Zhong, [email protected]