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IGF-1 LR3s Akt-FoxO3a-mediated suppression of ubiquitin-proteasome (Atrogin-1/MAFbx and MuRF-1 mRNA reduction 28-38%, measured by qPCR in denervation or dexamethasone atrophy models) and autophagy (ULK1 Ser-757 phosphorylation by mTORC1, LC3-II accumulation 22-28%) provides rapid, direct anti-catabolic signalling within 1-2 hours

Besides structural adaptations, exercise significantly elevates circulating biomarkers associated with cardiovascular disease, such as creatine kinase, cardiac troponin, and B-type natriuretic peptide (BNP) (45)