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Hypoxia-preconditioned BMSCs secrete functional paracrine molecules such as VEGF and miR-126, which not only inhibit right ventricular cardiomyocyte apoptosis, alleviate inflammation and fibrosis, but also improve pulmonary vascular remodeling and reduce mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) (De Mendona et al., 2017)

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These are promising results, but the studys authors note that more research is needed, and clinicians must also consider potential adverse effects, evaluate the cost-effectiveness of these medications for each patient, and closely monitor for any improvement or worsening of eating disorders and related side effects. That hesitation is shared by the National Eating Disorder Association (NEDA), who published an opinion paper on GLP-1s and eating disorders in 2024, stating: While there is some evidence that GLP-1s can decrease the number of binge eating episodes for those with BED, little is known about the long term physical and psychological impact on those with eating disorders. How GLP-1s could also fuel eating disorders The same mechanisms that make these medications helpful for some could make them harmful for others

But knowing something might happen and knowing what to do when it does happen are two very different things