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Several more lines of evidence derive from in vitro bio-mimetic studies and from experimental toxicology studies of inorganic and organic chemicals

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[17] [18] This rapid degradation necessitates the development of modified GLP-1 analogues or DPP-4 inhibitors to achieve sustained therapeutic effects

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Frias JP, Davies MJ, Rosenstock J et al (2021) Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes