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Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

After being extracted by gastric acid, it travels to the terminal ileum, where it is co-absorbed along with the intrinsic factor, an enzyme from the stomachs parietal cells (Fig

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