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All procedures for animal experiments in this study were authorized by the Institutional Animal Care and Use Committee (IACUC) of Seoul National University (Approval Number: 220038-S1A0) and complied with the guidelines for the care and use of laboratory animals

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By simultaneously enhancing protein synthesis through mTOR activation and reducing protein degradation through FoxO inhibition, IGF-1 LR3 shifts the net protein balance dramatically toward anabolism

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