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First, Sensing and Destruction: COFs, equipped with precisely integrated sensitizing units, efficiently respond to external stimuli (e.g., light, ultrasound, radiation) or endogenous triggers (e.g., H 2 O 2 ), generating intense local biochemical effects such as bursts of ROS, hyperthermia, or DNA damage ( Figure 2 ) (155, 156, 166)

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Changes in gene expression in lab settings do not automatically mean a predictable clinical outcome in humans taking a peptide

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated fas-casp8-bid-axis