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The parallels with caffeine and paraxanthine highlight the potential of 1-MX to confer similar neuroprotective and cognitive benefits, supporting its novelty to enhance cognition

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4.2 Dysbiotic microbiome stimulates cyclooxygenase-2 expression, affects gastric emptying, and induces GERD Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme that catalyzes the initiating step in the metabolism of arachidonic acid to prostaglandin H2 and is a precursor to prostaglandins such as prostaglandins, thromboxanes, and prostacyclins, which act as autocrine and paracrine lipid mediators in the maintenance of local homeostasis by mediating vascular function, wound healing, and inflammation (52)

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As a result, many countries with public health systems face distressing decisions about whether to reimburse these drugs and, if so, for which groups