* Therefore, in general, the non-oxidative phase as a whole serves to convert the ribose 5-phosphate from the oxidative phase into fructose 6-phosphate and glyceraldehyde 3-phosphate which are glycolytic intermediates involved in the production of Glucose 6-phosphate
10.1007/s10549-021-06454-7 Breast Cancer Res Treat
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Further, hypoxia in the tumor microenvironment promotes lactate accumulation, extracellular acidosis, VEGF overexpression, and VEGFR activation, all of which are known drivers of immune cell tolerance and immunosuppressive status (Mendler et al., 2012