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Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors

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Oestrogen dependence may be due to the upregulation of the 17-hydroxysteroid dehydrogenase-1 and aromatase genes, whereas progesterone resistance may result from the failure of progesterone receptor activation and transcription of progesterone target genes [99]

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They state It is clear that serum thyroid hormone and thyroid stimulating hormone concentrations cannot be used with any degree of confidence to classify patients as receiving satisfactory, insufficient, or excessive amounts of thyroxine replacement The poor diagnostic sensitivity and high false positive rates associated with such measurements render them virtually useless in clinical practice Further adjustments to the dose should be made according to the patients clinical response. Similar results were observed by Meier et al