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In cardiovascular system, LC and TMZ are not only influence cardiomyocytes but also may influence other systems working followed by indirectly feedback to cardiomyocytes

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Levels are also reduced in chronic kidney disease, making klotho a biomarker of renal function as well as aging

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The protein expression of the four genes in culture medium were further tested with ELISA kits

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Graphical abstract Access this article Similar content being viewed by others References Maenner MJ, Warren Z, Williams AR et al (2023) Prevalence and characteristics of autism spectrum disorder among children aged 8 years autism and developmental disabilities monitoring network, 11 sites, United States, 2020

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