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GIP, like GLP-1, is an incretin hormone secreted by intestinal K cells in response to nutrient intake

The current challenge thus is of first clarifying what is normal, as an absence of HE does not necessarily equal absence of neuropsychometric abnormality [14], and then determining optimal methods by which early HE can be consistently and accurately distinguished

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This increased efficacy is generally desirable, but patients already on insulin or other diabetes medications may require dose reductions to prevent hypoglycemia