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Then clinical practice

TMA is readily absorbed in the gastrointestinal tract and further processed by the hepatic enzyme flavin monooxygenase 3 (FMO3) to produce trimethylamine N -oxide (TMAO) (Lang et al

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Under these conditions, the increased secretion of counterregulatory hormones stimulates FFAs oxidation in the liver and accelerates the production of ketone bodies, which are metabolized in muscle, adipose tissue and, most importantly, in heart and brain (52)