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doi: 10.1016/j.appet.2020.104849, 27

The limiting variable is not the amount applied to the skin surface but the amount that reaches viable dermis

A review of GLP-1 agonist studies using the standard dose in high intracranial pressure reported: Patients should be counseled about the high likelihood of nausea and GI upset (diarrhea, vomiting, and constipation, delayed gastric emptying) especially in the first 48 weeks of therapy

The concerns I take seriously are the ones with a plausible mechanism mild headache in sensitive individuals, or caution for someone with a family history of vitiligo

it has not been tested in a human clinical trial