As in many other cancers, HCC progression is characterized by EMT with loss of epithelial markers (e.g., E-cadherin, ZO-1, Cytokeratin) and gain of mesenchymal markers (e.g., Vimentin, TWIST1, ZEB1, CD44, SNAI1, SNAI2) 38
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Psychosom Med 59(2):114127 Boyadjieva NI, Chaturvedi K, Poplawski MM, Sarkar DK (2004) Opioid antagonist naltrexone disrupts feedback interaction between and opioid receptors in splenocytes to prevent alcohol inhibition of NK cell function