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Journal of Clinical Oncology 22, 23882394 (2004)

Research on GLP-1 Medications for Treating SUDs Animal studies consistently demonstrate GLP-1 receptor agonists reduce alcohol, nicotine, and opioid consumption (Srinivasan et al., 2025)

Further, long-term use of acid-reducing drugs and the anti-diabetes drug metformin and repeated exposure to nitrous oxide have been implicated in vitamin B 12 deficiency (see Drug interactions)

For example, one early protocol for substance use disorders employed 500-1,000 mg of NAD+ per day delivered by slow intravenous infusion over several consecutive days

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