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Applying ice to the area 2-3 minutes before injection numbs the skin slightly and may reduce needle pain perception
Dose titration over 20 weeks (starting at 0.25mg weekly, increasing to 2.4mg) is critical for tolerating gastrointestinal side effects, which occur in 3045% of patients during escalation
These include: Mild nausea or digestive discomfort (more common with oral forms) Dizziness or lightheadedness Injection site irritation, redness, or swelling Possible changes in appetite These side effects typically go away on their own and do not pose long-term risks
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