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For an acute injury, users often report effects within the first cycle, and inflammatory markers like hs-CRP may shift within the first few weeks.

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Funding This work was supported by the National Natural Science Foundation of China (32002184 to BW), the ZhiYuan project of Inner Mongolia Medical University (ZY0120025 to LS), and the Key Technology Research, Development and Transformation Projects of Inner Mongolia (2021GG0402 to YD and 2022YFSH0102 to YM)

This risk is heightened by genetic variants such as the OATP1B1 R57Q polymorphism, which impairs drug transport and can lead to systemic toxicity (62, 63)