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They propose that this advantage may come from avoiding first-pass hepatic metabolism, achieving sustained systemic levels, and better interruption of inflammatory pathways such as COX-2mediated cascades

Lancet 397(10278):971984 Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D et al (2023) Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

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Aging is a complex biological process influenced by hormonal imbalances, oxidative stress, and cellular degeneration