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Deficiency in mitochondrial complex I is associated with mutations in various structural subunits and assembly factors, resulting in a wide range of clinical manifestations, including LHON, infantile LS, MELAS, and epilepsy (56)

TB-500 (a synthetic fragment of Thymosin Beta-4) works through anti-inflammatory and cell migration pathways

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Synovial cells cotransfected with miRNA-125 mimics, and PARP2-siRNA had significantly lower expression of pro-inflammatory cytokines, MMP-1, p-PI3K, p-Akt, and p-mTOR in comparison with the negative groups