In August 2025, Hengrui Medicine advanced its oral small-molecule GLP-1 candidate HRS-7535 into late-stage development, emphasizing local capability in producing affordable oral treatments that improve patient compliance
Additionally, CoQ10 binds to the mitochondrial permeability transition pore, preventing mitochondrial depolarization and cytochrome C release to lower cysteine protease-3 activation and reduce apoptosis (Hseu et al., 2018
Curr Drug Targets (2006) 7(11):143541.10.2174/1389450110607011435 87 HuMWuHChaoC
The advisory meeting was scheduled for 24 July 2026, so the document represented a staff proposal rather than a completed final determination
Quality control (QC) samples were prepared using the same procedure as tirzepatide standard working solutions, at final concentrations of 0.5, 8, 40, and 800 ng/mL as LLOQ, low, medium, and high QC, respectively