Variants predicted to significantly decrease stability, such as C23pAcF, I70pAcF, C96pAcF for PV2 and C23pAcF, I70pAcF, G119pAcF for PV3, were also included as controls
This is not a reason to start metformin on its own, but it is a relevant consideration if metformin is already part of the clinical conversation
Phosphorylation of eIF2 by PERK in response to ER stress decreases translation of mRNA and reduces stress (Harding et al , 2003)
was funded by a scholarship from the Mexican council for science and technology (CONACyT)
2 Materials and methods Approximately 90% of the papers mentioned in this review (total number of papers included in this review: 103) were found by a search in the Web of Science/Google Scholar databases using the keywords tendon injury, IGF-1, tendon regenerative healing, tendon repair, tenocyte, mechanisms (the search was performed during the period of May to September 2024 and only literature written in English was reviewed) (Figure 1)
