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These easily form cross-links to other cystines in the hair molecule

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While a variable number of Ahx spacers was inserted to minimize steric clash between the NLS and the MDM2-binding interface, the NLS containing stapled peptides showed comparable binding values for MDM2, and were found to have sub-micromolar affinity for importin in a direct fluorescence polarization (FP) assay

This lowers the excitatory effect of glutamate on NMDA receptors and enhances neuronal inhibition in the CNS

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