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Tirzepatide reduces hunger signals and increases fullness, leading to consistent calorie deficit and progressive weight loss

It's important to note that for patients with diabetes and CKD, the ADA and KDIGO now recommend SGLT2 inhibitors for kidney and cardiovascular protection independent of A1C levels, with metformin used when eGFR is adequate (30 mL/min/1.73 m) and tolerated

Progressive deformation of deep brain nuclei and hippocampal-amygdala formation in schizophrenia

If confirmed in Phase 3, this would substantially exceed semaglutide

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