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Two propensity score matched observational studies have been conducted to date, either evaluating suicidality risk in patients using semaglutide vs non-GLP-1RA glucose-lowering agents, or in those using any GLP-1RA vs users of dipeptidyl peptidase-4 (DPP-4) inhibitors

Ubiquitination often leads to proteasome-mediated degradation of the substrate, but can also result in altered location or activity 4,5,6

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