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Moreover, postmortem brains of depressed patients are reduced in size and show loss of pyramidal neurons (Rajkowska et al., 1999), GABAergic interneurons, and glia in the PFC (Rajkowska et al., 2007)

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These findings support the conclusion that retatrutide has clinically measurable activity in type 2 diabetes, but it remains unapproved and is not an established diabetes medicine