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PubMed: 16502757 AOD 9604 and Articular Cartilage Repair: Assessment in a Rat Cartilage Defect Model animal Black A, Huang AH, Yin Z, et al

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SB increases the fraction of cells in the G1 phase of the cell cycle and was suggested to exhibit its antiproliferative action via blocking the transition of the cell cycle from the G1 phase to the S phase or by arresting the cell cycle at the G1 phase ( When human uterine leiomyoma cells were being treated with SB, it was observed that c-fos mRNA expression was being induced by SB via the cAMP/PKA pathway which was activated by the increased in cAMP level ( c-fos gene expression ( c-fos is a proto-oncogene that is closely involved in cell growth and differentiation and was also suggested to be involved in smooth muscle cell differentiation ( c-fos gene expression has been identified to be significantly lower in leiomyoma cells as compared to normal myometrium which is consistent with the previous study that has suggested that a decrease in the smooth muscle cells progenitors could have contributed to the formation of UF ( c-fos expression in leiomyoma cells induced by SB is associated with its antiproliferative actions ( The higher incidence of UF and the greater fibroid size during the first trimester of pregnancy have suggested the role of hCG in the pathogenesis of UF ( SB has also been observed to down-regulate the expression of IGF-I in leiomyoma cells which were overexpressed in UF as compared to normal myometrium ( Euonymus alatus (Thunb.) Siebold [Celastraceae] for Uterine Fibroids Euonymus alatus (EA) is a medicinal plant used for the treatment of tumors in TCM and traditional Korean medicine

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Napolitano, Alessandra