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A US-licensed clinician will also screen for absolute contraindications: personal or family history of medullary thyroid cancer, Multiple Endocrine Neoplasia type 2, pregnancy or breastfeeding, history of pancreatitis, and active gallbladder disease

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In that trial, diarrhoea was reported in approximately 2030% of participants receiving higher doses of retatrutide, with rates varying by dose level and stage of titration