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10.1002/jnr.23397 J

This evidence base reveals a significant translational gap between extensive animal research and limited clinical validation in human subjects

Thus, the current body of evidence indicate that the combined use of vitamin D, MI, and melatonin is biologically plausible and may provide additive effects at both molecular and cellular levels

Interestingly, recent studies have shown that BDNF also plays significant roles outside the nervous system: loss of BDNF in cardiomyocytes leads to myocardial degeneration and heart failure 23

Clinical trials demonstrate that participants experienced up to a 35% improvement in skin smoothness and texture after consistent collagen supplementation