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Epps F, Heidbreder V, Alexander K, Tomlinson A, Freeman V, Williams N

Key findings at the highest dose (12mg weekly): Up to 24% mean body weight reduction over 48 weeks Significant reductions in fasting glucose and insulin resistance markers Meaningful reductions in liver fat content, relevant for participants with metabolic-associated fatty liver disease Once-weekly subcutaneous dosing was generally well-tolerated For context, semaglutide at its approved dose achieves approximately 1517% body weight reduction over 68 weeks

Specifically, the levels of type I collagen, elastin and sulfated GAGs are restored, although it does not cause a decrease in MMP1

The incidence of Keshan disease is closely associated with very low dietary intakes of selenium and poor selenium nutritional status

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