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For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures

Among the various pro-inflammatory factors, TNF can promote the production of extracellular matrix (ECM) and regulate the proliferation and differentiation of lens epithelial cells, but the roles of other factors in cataract formation need to be further investigated