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Here we present the antioxidant GSH as a potential unexplored way for further investigation as intervention to counteract inflammaging, premature inflammaging, inflammatory diseases and long-COVID-19-syndrome, since GSH levels are correlated with tissue and organ damage, disease severity and progression, and disease outcome (294296, 298, 299)

Oral and topical forms of GSH have shown moderate success in reducing melanin levels with minimal side effects, while intravenous use, though popular, raises significant safety concerns, including risks of anaphylaxis and liver damage

Some interactions may diminish its effectiveness or cause unwanted side effects

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A simplified explanation is that some of the homocysteine produced during methylation reactions is used to make cysteine, which is then combined with two other amino acids (glutamate and glycine) to form glutathione