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They found that it wasnt possible to determine a clear lower limit for which any of these biomarkers can reliably indicate B12 deficiency, but that daily intakes above 4.0 g appear to have no additional benefit

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tremor or shaking including so-called "pill-rolling" movements rigidity slowness of movement, including difficulty planning, initiating and executing movement, as well as hindrance of the performance of sequential and simultaneous movement rigidity i.e

The average age of onset is 15 years