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Moreover, GLP-1RA anti-catabolic effects can reduce cartilage degradation through the downregulation of TNF-mediated expression of catabolic enzymes, hence preserving essential components of the extracellular matrix such as type II collagen and aggrecan[15]

Journal of the Endocrine Society, 7 (4), bvad016

Retatrutide's addition of glucagon receptor agonism appears to provide the extra metabolic boost that results in even greater weight loss, which could be especially valuable for the metabolically challenged population with PCOS

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