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For instance, 16S rRNA sequencing of fecal samples revealed a distinct microbial shift in CRC patients compared to controls, characterized by a higher abundance of oral pathobionts including Parvimonas micra, Peptostreptococcus stomatis , and various Porphyromonas species (Lwenmark et al., 2024)

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370 ROS contribute to tumorigenesis through multiple processes, including causing oxidative DNA damage, genomic instability and inflammatory stress to drive malignant transformation, and acting as a messenger to regulate signaling pathways to support tumor initiation, development, and angiogenesis