These findings suggest that moderate hypoxic preconditioning does not globally enhance USC-derived trophic factor secretion, but instead induces a more selective, VEGF-dominant pro-angiogenic secretory response
Circ Res 2007;100:170311
Conclusions As discussed above, the role of amino acids in supporting or inhibiting tumor biology and antitumor immune responses can be variable, depending on the tumor type, its mutations, infiltrated immune cells, the presence of other molecules, the biochemical conditions in the TME (oxygen levels, etc), and the metabolism of the cells from the TME, influencing, for example, how they use the amino acids, as a carbon source or as a substrate for enzymes or PTMs
anything that blunts acidity or adds competing ligands in the stomach worsens uptake
Follicles that have been miniaturized or dormant for shorter periods tend to respond more robustly than those that have been compromised for years or decades