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Neurological problems from B12 deficiency may be permanent

Designing vitamin D3 formulations: an in vitro investigation using a novel micellar delivery system

PMID: 41966639 | doi:10.1007/s40279-026-02437-0

While some are good for several weeks or even months after opening, others must be used within a few days max

Warnings: Patients with early Leber's disease (hereditary optic nerve atrophy) may experience severe and rapid optic atrophy when treated with vitamin B12. Additionally, treating severe megaloblastic anemia with vitamin B12 can lead to fatal hypokalemia due to increased erythrocyte potassium requirements