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Notably, compared with A-CDs, AA-CDs significantly increased safranin O and toluidine blue staining intensity, significantly upregulated the expression of COL2 and ACAN, and downregulated the expression of MMP13
The peptide also shows potential DHT protection through copper ions inhibiting up to 90% of type 1 5-alpha reductase at specific concentrations, which targets the enzyme most involved in hair follicle miniaturization
We hypothesized that GSH synthesis plays additional detoxification-independent roles in liver function
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