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The STEP 1 trial gives clear data on how much weight people lost over time with semaglutide 2.4 mg compared to a placebo

This nuanced understanding is why researchers trust our Metabolic & Weight Research insights

Substantial and rapid reductions in body fat leave more excess skin

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Implications for practice Following more than 6 months where initiation of GLP-1 RAs was not permitted in the UK, clinicians will have been pleased to read the National Drug Safety Alert published earlier this month, which confirms that there are now sufficient supplies of daily oral semaglutide (Rybelsus) available in the UK to allow new initiations as well as supplying those already on treatment