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Rather than targeting symptoms in isolation, this combination addresses the full architecture of the menopausal disruption: the hormonal withdrawal and the metabolic environment it creates, simultaneously and through mechanisms that reinforce one another
They minimize systemic inflammation by many mechanisms: direct suppression of pro-inflammatory cytokine synthesis (TNF-, IL-6, IL-1), augmentation of anti-inflammatory mediators (IL-10, adiponectin), and alteration of immune cell morphologies
The clinical significance was highlighted by Lilly's leadership: "Obesity is a chronic, progressive disease, and sustaining weight loss remains a significant challenge for many," said Kenneth Custer , Ph.D., executive vice president and president, Lilly Cardiometabolic Health
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