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10.1038/s41420-022-01199-8 196 OlivierA

Semaglutide-treated patients showed significantly greater reductions in ASMI, handgrip strength and gait speed compared to controls (see Table 2)

In a phase 2 randomised controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023), participants receiving the highest doses of retatrutide achieved a mean weight reduction of approximately 1724% of body weight over 48 weeks, depending on dose

The gut hormones PYY 336 and GLP-1 736 amide reduce food intake and modulate brain activity in appetite centers in humans