4 Materials and methods 4.1 Cell culture and in vivo experiments 4.1.1 Cell lines Four human NB cell lines were used in this paper: Be(2)-C (MNA), IMR5-/75-shMYCN (29) (MNA, doxycycline-inducible shRNA targeting MYCN, resulting in MYCN downregulation), IMR-32 (MNA), and SH-SY5Y/6TR(EU)/pTrex-Dest-30/MYCN (non-MNA, doxycycline-inducible transgene, resulting in MYCN overexpression)
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For weight management, medications like Wegovy and Zepbound are FDAapproved for obesity treatment when: BMI is 30 or higher BMI is 27 or higher with weightrelated health conditions The patient has tried and failed nondrug interventions such as diet and exercise Cost and Why Its Out of Reach for Many At retail price, GLP1 medications can cost over $1,000 per month
After losing its market edge to Eli Lilly (NYSE: LLY) despite its first-mover advantage in weight-loss drugs, Novo Nordisk is trying to close the gap
