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Semaglutide is eliminated primarily through peptide degradation and glomerular filtration, not hepatic metabolism, which means it does not compete with HRT for liver enzyme systems like cytochrome P450

In 2025, Williams opened up about her experience taking Zepbound, citing not only weight loss but improved health overall

The preliminary and unpublished findings, which were presented at the Research Society on Alcohols Annual Meeting, showed a reduction in heavy drinking and drinking quantity among those who were given semaglutide versus the placebo group

Baseline body makeup influences the magnitude and timeline of changes, with subjects starting at higher body fat percentages possibly showing more rapid fat loss

These usually occur during the initial dose increase phase and often subside within a month