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Taken together, these results may suggest that GLP-1 is an important mediator of the stress response in the brain

Combination Therapy: Safety and Clinical Considerations When HRT and GLP-1 therapies are used together, the primary challenge shifts from isolated risk management to integrated physiologic balance

Reported side effects included: Nausea Vomiting Diarrhoea Constipation Higher doses were associated with increased side effects

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During the 80-week trial, participants lost an average of 28 percent of their body weight (roughly 70 pounds) on the highest dose of retatrutide, while nearly half shed 30 percent of their weight or more