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Eight major RCTs of GLP-1RAs have investigated the cardiovascular outcomes, including the ELIXA trial of lixisenatide (250), the EXSCEL trial of exenatide ER (251), the LEARDER trial of liraglutide (252), the SUSTAIN-6 trial of subcutaneous semaglutide (253), the HARMONY trial of albiglutide (228), the REWIND trial of dulaglutide (254), the PIONEER trial of oral semaglutide (255), and the SELECT trial of subcutaneous semaglutide (199)

Hart, H.M

Furthermore, combination therapies that target multiple metabolic pathways, including glutamine metabolism, may enhance treatment outcomes and overcome resistance

The long-term profile requires patience and ongoing monitoring

The reaction is only terminated once two radicals react with one another or with an antioxidant molecule (43, 44, 57, 58)