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Histamine H2 receptor antagonists, such as cimetidine ( Tagamet ), famotidine ( Pepcid ), and ranitidine ( Zantac ), that are used to treat peptic ulcer disease

To find the best concentration levels, formulators should look at relevant clinical literature and think about doing dose-response studies while the product is being developed

Rare risks include copper toxicity, particularly in individuals with underlying conditions such as Wilsons disease (a genetic disorder causing copper accumulation), and theoretical concerns regarding angiogenesis promotion in the context of active cancers

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This may be attributed to methodological difficulties that preclude performing this kind of studies as they require longer durations of follow up