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GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors

A phase II study of depsipeptide in refractory metastatic renal cell cancer

Appropriate pediatric doses were predicted to achieve similar drug exposures to that in adults

The effect of force exerted by the jet injector (loading) in the normal and axial direction during injection has been reported in an earlier study [35], and therefore we used a recommended normal load of 1 kg for the maximum delivery efficiency at which the injection was actuated

Too much PEEP overstretches open units (overdistension)