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This DNA production and gene expression cannot happen as abundantly as required for the growing baby This process causes developmental disorders to occur in offspring, including neural tube defects, congenital heart disease, Downs Syndrome and cleft lip/palate 4 MTHFR treatment and ways to support the methylation process A variety of factors contribute to how efficiently your methylation cycle runs. Factors such as vitamin intake, alcohol intake and exposure to chemicals can all modify the way you methylate