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The peptide's small molecular weight (0.39 kDa) enables it to interact directly with DNA and act as an epigenetic regulatory factor, modulating chromatin structure and gene accessibility in neural tissue

Many peptides have low oral bioavailability because stomach acid and digestive enzymes break them down before they are absorbed

While most intracellular glutathione is in a reduced state (GSH) with approximately 1% as an oxidized form (GSSG), this proportion can decrease in response to a variety of cellular stressors, including heavy metals, high glucose concentrations, poor nutrition, heat shock, reactive oxygen and nitrogen species, cigarette smoke, and other toxins including persistent organic pollutants

Bcl-2 / Bax ratio A molecular "survival score." Bcl-2 is an anti-apoptotic protein that protects cells from death